Blackwell Research Institute is proud to highlight the exceptional work of Hannah Herskovic, a high school student from American Heritage High School in Boca-Delray, whose recent research project explores one of the most urgent scientific and public health questions of our time: the early biological origins of Alzheimer’s disease.

Through the Blackwell Research Institute, Hannah spent the past several months investigating how oxidative stress and mitochondrial dysfunction may serve as early drivers of Alzheimer’s - long before hallmark symptoms or clinical diagnosis appear. Her paper synthesizes findings across molecular biology, neuroscience, and disease pathology and offers an increasingly recognized perspective on how Alzheimer’s begins at the cellular level.

Hannah’s research revealed several striking insights, including emerging evidence that Alzheimer’s may start far earlier than commonly believed. One finding in particular stood out:

‍“Markers of oxidative stress have been detected in individuals at the mild cognitive impairment (MCI) stage… before plaque accumulation or tau tangle formation.”

‍This insight reflects a growing scientific consensus: disruptions in mitochondrial function and cellular energy production may play a key role in the earliest stages of cognitive decline. Hannah’s work brings clarity to a complex area of research and highlights promising avenues for early detection and intervention.

Her paper represents an impressive academic achievement for a high school student and demonstrates the depth, rigor, and creativity that the Blackwell Research Institute aims to foster in its scholars. Hannah is also a finalist for the 2026 Blackwell Impact Award, which recognizes students whose research advances scientific understanding and has the potential for long-term real-world impact.

Her work carries special meaning for her community. South Florida has one of the highest Alzheimer’s rates in the United States, affecting thousands of families across Miami-Dade, Broward, and Palm Beach counties. By examining early biological warning signs, Hannah’s research contributes to a broader effort to better understand, anticipate, and ultimately prevent the progression of this devastating disease.

“Hannah approached this project with remarkable dedication and intellectual curiosity,” said the publishing committee at Blackwell. “Her ability to engage deeply with emerging scientific literature and articulate the significance of early Alzheimer’s mechanisms is extraordinary for a high school student. She represents exactly the kind of young researcher we aim to empower.”
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Hannah’s full research paper is available through the Blackwell Research Institute for readers interested in exploring her analysis in greater detail. Her work stands as an inspiring example of how motivated students can contribute meaningfully to scientific progress when supported by strong mentorship and research training.As Hannah continues her academic journey, we look forward to seeing how her interest in cellular and molecular biology evolves - and how her work may help shape future advancements in neuroscience and public health.